Clinical results of updating method of a photodynamic therapy with Photosens :use as transport protein human albumines and fractional injection.
Torshina Nadezhda L.1, Kharnas Sergey S.2,Possypanova Anna M.1 , Volkova Anna I.1,
Kusin Michael2, Sclyanskaya Olga A.2, Kogan Eugenia A.2
1 General Physics Institute
38 Vavilov st., Moscow 117465, Russia
2Medical Academy, clinic of surgeonly decease ?1
6 B. Pirogovskaya st., Moscow 119435, Russia
At present we are carried out clinical tests of a compound PHOTOSENS for photodynamic therapy (PDT). PHOTOSENS is composition of the sulfonated of the phtalocyanines aluminium with a different degree of sulfonation (PhA). The necessity of dozes reduction PHOTOSENS (connected from it phototoxicity by use high doze) at a simultaneous increase of its accumulation and uniform distribution in tumor, as well as increase difference of the contents compound in tumor and a normal tissue cause us to search probable ways of the decision of this problem in the introduction of compound together with transport protein as well as in the divisible injection of small dozes PHOTOSENS. Is carried out study of distribution it in organism and interaction with biological structures.