Can photodynamic dose be predicted on
sensitizers photophysical parameters?
G.Streckyte, D.Frolov, S.Bagdonas, P.Juzenas and R.Rotomskis
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- Vilnius University
- Laser Research Center
- Sauletekio al. 9, C. III
- 2040 Vilnius, Lithuania
- Phone: (370 2) 76 94 77
- Fax: (370 2) 77 56 23
- E-mai: ricardas.rotomskis@ff.vu.lt
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ABSTRACT The traditional dosimetric approach, measuring each dose
factor independently, may be contrasted with the recent trend to use photosensitizer
photobleaching as an index of the effective delivered dose. The advantages and limitations
of photophysical parameters for the evaluation of effective dose are discussed. The need
to understand a degree to which the interaction of sensitizer with biological environment
as well as pH value of the surrounding is linked to the phototransformation process of
photosensitizer is analyzed. Possible changes in photobleaching rate of the sensitizer
dependently on its location sites and pH value of the surrounding are discussed. Finally,
the influence of the red-absorbing photoproduct formation on the dosimetry is considered. CONTENT
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